《計算機應用研究》|Application Research of Computers

DNA邏輯計算模型的研究現狀與展望

Research status and prospect of DNA-based logic computing models

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作者 趙云彬,周士華
機構 大連大學 先進設計及智能計算省部共建教育部重點實驗室,遼寧 大連 116622
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文章編號 1001-3695(2019)11-001-3201-09
DOI 10.19734/j.issn.1001-3695.2018.07.0512
摘要 DNA計算因其優異的計算能力已經成為當前研究熱點,DNA邏輯計算模型是DNA計算體系與運算實現的重要依托。按應用技術將現有DNA邏輯計算模型進行分類:基于鏈置換的DNA邏輯計算模型、基于核酶的DNA邏輯計算模型、基于G-quadruplex的DNA邏輯計算模型、基于DNA自組裝的邏輯計算模型、基于其他分子技術和分子材料的DNA邏輯計算模型。首先闡述了DNA邏輯計算的研究背景和研究目的以及現階段在生物分子檢測、疾病診斷、多因素分析和生物成像等領域的應用并簡述其相關概念;然后梳理各DNA邏輯計算模型的研究歷史和現狀,分析各類邏輯計算模型所應用的分子操控技術和分子材料以及優缺點和應用前景;最后歸納總結了DNA邏輯計算領域當前研究熱點和發展前景,為未來提出全新的計算方式奠定基礎,也為信息、醫療等領域提供更好的服務。
關鍵詞 DNA計算; DNA邏輯計算模型; 鏈置換; 核酶; 自組裝; 雜交鏈反應
基金項目 國家自然科學基金資助項目(61425002,61402067,61772100,61572093,61402066,61672121,61672051)
國家教育部“長江學者和創新團隊”發展計劃資助項目(IRT_15R07)
遼寧省創新團隊支持計劃資助項目(LT2015002)
遼寧省教育廳重點實驗室基礎研究項目(LZ2014049,LZ2015004)
遼寧省高校科學研究基金資助項目(L2015015)
本文URL http://www.ziusle.tw/article/01-2019-11-001.html
英文標題 Research status and prospect of DNA-based logic computing models
作者英文名 Zhao Yunbin, Zhou Shihua
機構英文名 Key Laboratory of Advanced Design & Intelligent Computing of Ministry of Education,Dalian University,Dalian Liaoning 116622,China
英文摘要 DNA computing has become a hot topic in current research due to its excellent computing performance, and DNA logic computing models is an important implementation tool for DNA computing system and computing implementation. Existing DNA logic computing models are classified according to application technology: DNA logic computing models based on strand displacement, DNA logic computing models based on nucleic acid enzymes, DNA logic computing models based on G-quadruplex, DNA logic computing models based on self-assembly, DNA logic computing models based on other molecular technologies and molecular materials. Firstly, this paper described the research background and research purposes of DNA logic computing and its applications in biomolecular detection, disease diagnosis, multi-factor analysis and bioimaging. Then, this paper sorted out the research history and current status of various types of DNA logic computing models, and analyzed the molecular manipulation techniques and molecular materials used in various logic computing models, as well as the advantages and disadvantages and application prospects. Finally, this paper summarized the current research hotspots and development prospects in the field of DNA logic computing, laying the foundation for a new calculation method for the future, and providing better services for information science, medical diagnosis and other fields.
英文關鍵詞 DNA computing; DNA logic computing models; strand displacement; nucleic acid enzymes; self-assembly; hybridization chain reaction
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收稿日期 2018/7/3
修回日期 2018/11/5
頁碼 3201-3209
中圖分類號 TP301.5
文獻標志碼 A
中超外援名额